Hotter bodies fight infections and tumours better – researchers show how

Science Daily | May 2018 | Hotter bodies fight infections and tumors better — researchers show how

Researchers from the Universities  of Manchester and Warwick have shown how individuals with higher body temperatures are better equipped to fight infections and tumours.  A Multidisciplinary team were involved in the study, with mathematicians from Warwick calculating how temperature increases make the cycle accelerate.  The researchers have demonstrated that small rises in temperature (such as during a fever) speed up the speed of a cellular ‘clock’ that controls the response to infections — and this new understanding could lead to more effective and fast-working drugs which target a key protein involved in this process (Science Daily).
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Higher body temperatures speed our bodies’ responses to infections, wounds and tumours – researchers at the Universities of Warwick and Manchester prove that a slight increase in body temperature and inflammation – such as a fever – speeds up cellular ‘clock’ in which proteins switch genes on and off to respond to infection.

  • Slight rise in temperature and inflammation – such as a fever – speeds up cellular ‘clock’ in which proteins switch genes on and off to respond to infection
  • New understanding could lead to more effective and fast-working drugs which target a key inflammation protein found to be critical for the temperature response
  • Interdisciplinary team of Warwick mathematicians and Manchester biologists used modelling and lab experiments to jointly make discovery (University of Warwick)

The full news item from Science Daily can be read here 

University of Warwick Hotter bodies fight infections and tumours better – researchers show how

The research is published in the Proceedings of the National Academy of Sciences

The full article is available to read here

Full reference:

Harper, C. V. , et al | Temperature regulates NF-κB dynamics and function through timing of A20 transcriptionProceedings of the National Academy of Sciences | 2018; 201803609|  DOI: 10.1073/pnas.1803609115

 

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