NIHR Signal: Combining mirtazapine with other antidepressants is not effective for treatment-resistant depression

NIHR | February 2019|Combining mirtazapine with other antidepressants is not effective for treatment-resistant depression

An NIHR Signal is highlighting the findings of a trial that found adding mirtazapine to first-line antidepressants for adults with treatment-resistant depression does not improve symptoms when compared with placebo (dummy pills). People taking mirtazapine are more likely to experience side effects, and stop taking their treatment.

This NIHR-funded trial took place in 106 general practices in England, recruiting 480 adults with mild to severe depression. All participants had been taking selective serotonin reuptake inhibitor (SSRI) or serotonin-noradrenaline reuptake inhibitor (SNRI) antidepressants for at least six weeks but were still depressed.

Read the NIHR Signal here 

Read our blog post on this Study finds combining mirtazapine with other antidepressants is not effective for treatment-resistant depression in a sample of depressed patients

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