The Office of Health Economics’ (OHE) informs decision making about health care and pharmaceutical issues at the UK, regional and international levels.
In light of concerns that not all medicines for ultra-rare (also known as ultra-orphan) conditionsare appraised under the same NICE process, a new OHE Consulting Report discusses the distinct ethical and economic challenges faced by medicines for ultra-rareconditions, with particular reference to the challenges of HTA in the UK. Afailure to consistently consider all ultra-rare disease medicines under the HST process could lead to inequalitiesin access and health outcomes for patients with ultra-rare conditions (Source: OHE)
The King’s Fund | January 2020| The economic influence of the NHS at the local level
A new long read from the King’s Fund has been written to help people working in the NHS understand the level of economic influence their organisations can have and the benefits this can bring to local populations, in a way they may not have considered before (Source: The King’s Fund).
Full reference: Zhou, B. |2020| Mindfulness interventions for rheumatoid arthritis: A systematic review and meta-analysis| Complementary Therapies in Clinical Practice, 101088|
A new systematic review and meta-analysis into rheumatoid arthritis finds that mindfulness interventions, as a complementary therapies in clinical practice, can significantly improve pain intensity, depression, and symptoms in patients with rheumatoid arthritis.
Other highlights of the study’s findings include:
Adverse effects accompanying the use of mindfulness interventions were not pinpointed in all the studies.
The authors suggest that we need to make full use of the Internet to link the mindfulness interventions line (in hospital) and online (outside the hospital), such as developing mindfulness meditation App, orienting courses and online psychological counseling.
To explore the effect of mindfulness interventions in improving outcomes for patients with rheumatoid arthritis.
Following the collective strategy of Cochrane Collaborative Group, the Cochrane Library, PubMed, EMBASE, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, and Wanfang Database were searched from the establishment of databases to September 2019. Reference lists were searched for additional studies. Risk of bias was assessed using Revman 5.3. Disagreement was resolved by discussion.
A total of 6 RCTs were included, including 337 patients. The results showed that the improvement of pain intensity in mindfulness group after intervention was better than that in the control group, and the difference was significant. There were significant differences in depression between the two groups. The results showed that there were significant differences in DSA28 between the two groups. The results showed that there were no significant differences in anxiety and CPR between the two groups.
mindfulness interventions can significantly improve pain intensity, depression, and symptoms in patients with rheumatoid arthritis compared with conventional therapy. But the result still needs to be confirmed by more high-quality, large-sample randomized controlled trials.
The Library can provide the full article to Rotherham NHS Staff, request here
New report shows that HIV transmission in the UK has continued to fall | Public Health England
This report provides an overview of the HIV epidemic in the UK up until the end of 2018. The report shows that thanks to increases in HIV testing, fewer people remain unaware of their HIV status.
The drop in HIV transmission has been especially large among gay, bisexual and other men who have sex with men from an estimated 2,800 transmissions in 2012 to 800 in 2018, a 71.4% fall. The number of gay, bisexual and men who have sex with men living undiagnosed with HIV has halved since 2014 from an estimated 7,000 to 3,600 in 2018.
The scale-up of combination prevention (which includes the use of condoms, HIV testing in a wide range of settings, starting antiretroviral therapy (ART) as soon as possible if positive, and the availability of Pre-exposure Prophylaxis (PrEP) for those who are negative) across the UK is working.
This report also focuses on five strategies that are key to future HIV control and prevention:
HIV testing policies
Clinical Care and Treatment as Prevention (TasP)
Notification of partners of persons newly diagnosed with HIV (Partner Notification)
Pre-exposure prophylaxis (PrEP)
HIV prevention services for people who inject drugs.
Alzheimer’s Research UK has called on government to invest in six priority research areas, which will help to deliver a life-changing treatment for dementia
In their 2019 manifesto, the Conservative party pledged to launch a “Dementia Moonshot” to find a cure for dementia – doubling research funding and speeding up trials for new treatments.
Alzheimer’ Research UK are now calling for action to deliver on those commitments. In this publication, Alzheimer’s UK puts forward the steps government must take to deliver its Moonshot ambition of finding a life-changing treatment for dementia.
Find ways to detect the diseases that cause dementia 10-15 years earlier, to broaden the search for new treatments and intervene with those most at risk of developing dementia.
Find ways to more effectively validate novel targets in early drug development to maximise chances of successful clinical trials.
Make the UK the best place to conduct clinical dementia research.
Expand research infrastructure to maintain the UK’s position as a world leader in dementia research.
Further our understanding of dementia risk reduction and prevention and dementia in the context of multi-morbidities.
This briefing reflects on the progress that has been made to increase investment in mental health services and deliver on aspirations to improve service provision. It also gives NHS Providers’ view on the solutions needed to address the financial and investment challenges facing the sector.
Mental health services have had a substantial cash injection in recent years. Following a decade of significant campaigning from the mental health sector, there is widespread support for greater investment in mental health services. In recent years aspirations to improve quality and access to services has taken shape with the development of a fully costed programme for mental health delivery with The Five year forward view for mental health. The NHS long term plan published since is clear that making further progress on improving people’s mental health and wellbeing is a priority for the next decade.
This briefing looks at the financial and investment challenges facing mental health providers. It digests the financial and funding issues facing mental health trusts, including their current financial position, the impact of stigma on investment in mental health provision, how mental health services are commissioned, contracted and paid for, the transparency and governance of funding flows, as well as setting out a number of solutions to financial problems mental health trusts face.
This study examines the evidence base on UK pregnancy research needs and priorities and how it compares to the current funding landscape. The report indicates the NHS spends significantly less on pregnancy-related research compared with other health conditions.
Funding for pregnancy research totalled £255 million from 2013 to 2017, or about £51 million a year. As pregnancy care costs the NHS £5.8 billion annually, this means that for every £1 spent on pregnancy care, less than 1 penny is spent on research.
The study found that this investment is much lower than for conditions such as heart disease – 7p for every £1 spent on care – and cancer – 12p for every £1.
The report, commissioned by the UK Clinical Research Collaboration, shows that the £255 million spent on pregnancy research accounts for about 2.4 per cent of all direct, non-industry health research.
£51m per year is invested in pregnancy research in the UK.
For every £1 spent on pregnancy care in the NHS, around 1p is spent on research.
Mental health research is the top priority for all stakeholders and is likely underfunded.
Other priority topics are varied, spanning stillbirth, preterm birth, inequalities, postnatal support, and safety of medications during pregnancy. The level of funding currently provided differs across the topics identified as priorities.