This progress report provides an update on the work that Health Education England (HEE) has completed with partners including the British Medical Association, the Academy of Medical Royal Colleges and the General Medical Council over the past year in response to the concerns doctors in training have raised and to help boost morale (HEE).
Science Daily | May 2018 | Hotter bodies fight infections and tumors better — researchers show how
Researchers from the Universities of Manchester and Warwick have shown how individuals with higher body temperatures are better equipped to fight infections and tumours. A Multidisciplinary team were involved in the study, with mathematicians from Warwick calculating how temperature increases make the cycle accelerate. The researchers have demonstrated that small rises in temperature (such as during a fever) speed up the speed of a cellular ‘clock’ that controls the response to infections — and this new understanding could lead to more effective and fast-working drugs which target a key protein involved in this process (Science Daily).
Higher body temperatures speed our bodies’ responses to infections, wounds and tumours – researchers at the Universities of Warwick and Manchester prove that a slight increase in body temperature and inflammation – such as a fever – speeds up cellular ‘clock’ in which proteins switch genes on and off to respond to infection.
Slight rise in temperature and inflammation – such as a fever – speeds up cellular ‘clock’ in which proteins switch genes on and off to respond to infection
New understanding could lead to more effective and fast-working drugs which target a key inflammation protein found to be critical for the temperature response
Interdisciplinary team of Warwick mathematicians and Manchester biologists used modelling and lab experiments to jointly make discovery (University of Warwick)
The full news item from Science Daily can be read here
Harper, C. V. , et al | Temperature regulates NF-κB dynamics and function through timing of A20 transcription| Proceedings of the National Academy of Sciences | 2018; 201803609| DOI: 10.1073/pnas.1803609115
Scleroderma & Raynaud’s UK | World Scleroderma Day
This month (June 2018) is Scleroderma Awareness month, to help raise awareness of this autoimmune condition. Scleroderma is a rare, chronic disease of the immune system, blood vessels and connective tissue. 2.5 million people worldwide have scleroderma, and in the UK there are 12,000 people diagnosed. It is a severe condition and can be fatal. Scleroderma & Raynaud’s UK (SRUK) have created a number of resources. #WorldSclerodermaDay is on 29th June. (Source: SRUK)
University College London| June 2018 | Almost 1 in 4 people worldwide to be obese by 2045
Research presented in Austria at the recent European Congress on Obesity in Vienna, Austria (23-26 May) indicates that if obesity levels continue at their current rates, 25 per cent of the population will be obese by 2045.
Researchers from University College London (UCL), Medical Anthropology, were involved in the discovery that to prevent of type 2 diabetes from going above 10% in 2045, global obesity levels must be reduced by 25%, from 14% to just over 10%.
For example, in the United Kingdom, current trends predict that obesity will rise from 32% today to 48% in 2045, while diabetes levels will rise from 10.2% to 12.6%, a 28% rise. To stabilise UK diabetes rates at 10%, obesity prevalence must fall from 32% to 24% (via UCL).
The full news item is available from UCL
Winter 2017/18 saw an unprecedented demand for health and care support services. Emergency departments bore the brunt of this demand. This report features practical solutions from staff and calls for wider action for health and social care services to work together | Care Quality Commission
This report aims to contribute to the discussion about how those working in health and social care can come together in a more systemised way to encourage early and effective planning for not only winter pressures but for all periods of peak demand.
The report suggests that there is a need to develop a shared understanding of what an effective escalation strategy looks like – and longer-term, how health and care providers and commissioners collaborate to meet the needs of their local populations, with a stronger focus on keeping people well and helping them stay out of hospital.
The report concludes that the ongoing trend of increasing demand on health and social care services is not abating and it is clear that action is needed now to address the pressures on emergency departments, and in turn keep patients safe. Whilst the report recognises that there are no simple solutions to this problem, it identifies examples of good practice and potential immediate steps to take to manage these issues.
Nuffield Trust | June 2018 | Emergency readmissions to hospital for potentially preventable conditions on the rise, new research shows
Data analysed by the Nuffield Trust shows that readmissions within 30 days of discharge for preventable conditions such as pneumonia and pressure sores increased by almost a fifth (19 per cent) between 2010/11 and 2016/17.
The new findings from QualityWatch, a major research programme from the Nuffield Trust and the Health Foundation, looked at hospital data detailing patient diagnoses and the reasons behind emergency hospital readmissions during this time (Nuffield Trust).
Between 2010/11 and 2016/17, the number of emergency readmissions within 30 days increased from 1,157,570 to 1,379,790, a rise of 19.2%. The proportion of patient hospital stays that were followed by a readmission grew from 7.5% to 8%.
Potentially preventable emergency readmissions to hospital grew from 130,760 to 184,763 – an increase of 41.3%. This means that the proportion of patient hospital stays that were followed by these types of readmission grew from 0.8% in 2010/11 to 1.1% in 2016/17.
Patients readmitted to hospital in an emergency with pneumonia increased from 41,003 in 2010/11 to 70,731 in 2016/17, an increase of 72.5%. The increase in pneumonia readmissions was greater than the overall increase in pneumonia cases.
Emergency readmissions for pressure sores almost trebled from 7,787 in 2010/11 to 22,448 in 2016/17. The increase in the number of patients being readmitted with a pressure sore superseded the overall increase in the number of pressure sore diagnoses in hospital.
The number of patients readmitted with venous thromboembolism grew by a third, from 16,890 in 2010/11 to 23,006 in 2016/17.
The full press release from the Nuffield Trust is available here