University of Glasgow | May 2018 | New grip strength test could be used to identify patients at high risk of range of diseases
A new research study from the University of Glasgow’ s Institute of Cardiovascular and Medical Sciences has found that high grip strength was linked to a reduced risk of all causes of mortality. By contrast, a weak grip was associated with poorer health outcomes such as cardiovascular disease and cancer. The findings have now been published in the BMJ, where the paper can be read in full
The full news item can be read at the University of Glasgow
Objective To investigate the association of grip strength with disease specific incidence and mortality and whether grip strength enhances the prediction ability of an established office based risk score.
Design Prospective population based study.
Setting UK Biobank.
Participants 502 293 participants (54% women) aged 40-69 years.
Main outcome measures All cause mortality as well as incidence of and mortality from cardiovascular disease, respiratory disease, chronic obstructive pulmonary disease, and cancer (all cancer, colorectal, lung, breast, and prostate).
Results Of the participants included in analyses, 13 322 (2.7%) died over a mean of 7.1 (range 5.3-9.9) years’ follow-up. In women and men, respectively, hazard ratios per 5 kg lower grip strength were higher (all at P less than 0.05) for all cause mortality and cause specific mortality from cardiovascular disease, all respiratory disease, chronic obstructive pulmonary disease, all cancer, colorectal cancer, lung cancer, and breast cancer but not prostate cancer. Several of these relations had higher hazard ratios in the younger age group. Muscle weakness (defined as grip strength less than 26 kg for men and less than 16 kg for women) was associated with a higher hazard for all health outcomes, except colon cancer in women and prostate cancer and lung cancer in both men and women. The addition of handgrip strength improved the prediction ability, based on C index change, of an office based risk score (age, sex, diabetes diagnosed, body mass index, systolic blood pressure, and smoking) for all cause and cardiovascular mortality and incidence of cardiovascular disease.
Conclusion Higher grip strength was associated with a range of health outcomes and improved prediction of an office based risk score. Further work on the use of grip strength in risk scores or risk screening is needed to establish its potential clinical utility.
Full reference: Celis-Morales, Carlos A. et al |Associations of grip strength with cardiovascular, respiratory, and cancer outcomes and all cause mortality: prospective cohort study of half a million UK Biobank participants |BMJ 2018|361 |doi: https://doi.org/10.1136/bmj.k1651